Bilimsel Gündem

Differentiating HFmr/rEF from HFpEF using standard 12-lead ECG measurements: an interpretable machine learning study(yeni sekmede açılır)

Zhao, C., Chan, P. J., Dougherty, S., Fan, Y., Lee, A. P. W.

Background Differentiating heart failure (HF) with mildly reduced/reduced ejection fraction (HFmr/rEF) from HF with preserved ejection fraction (HFpEF) guides therapy but echocardiography may be delayed or unavailable. We developed and validated machine learning models using routine 12-lead ECG data to classify HF…

Resting heart rate and long-term mortality in young adults: a population-based cohort study(yeni sekmede açılır)

Chen, H., Chen, Q., Wang, Y.

Objectives Elevated resting heart rate (RHR) predicts mortality in middle-aged and older adults, primarily through cardiovascular disease (CVD). Whether RHR predicts mortality in young adults, which causes of death are involved and whether the association replicates are unclear. In young US adults, who fall below the…

Correction: Early versus delayed EKOS thrombolysis in intermediate-high risk pulmonary embolism: a retrospective multicentre analysis(yeni sekmede açılır)

Incidence of post-procedural atrial fibrillation after multivessel percutaneous coronary intervention versus coronary artery bypass grafting: a nationwide observational study(yeni sekmede açılır)

Sunnefeldt, E., von Koch, S., Mohammad, M. A., Erlinge, D., Frobert, O., Björkenheim, A.

Background Postoperative atrial fibrillation (AF) is a common complication after coronary artery bypass grafting (CABG) but is less well characterised after multivessel percutaneous coronary intervention (MV-PCI). With the increasing use of MV-PCI, we compared the incidence and clinical implications of clinically…

AI-enhanced electrocardiography as a digital biomarker platform in cardiovascular medicine: clinical applications, validation gaps and future implementation pathways(yeni sekmede açılır)

Venturiello, D., Vignaroli, W., Nasso, G.

Artificial intelligence applied to the ECG is expanding the clinical role of this widely available diagnostic tool beyond conventional waveform interpretation by enabling identification of electrophysiological patterns associated with cardiovascular structure, function and risk. Within this evolving framework, the…

Prevalence and burden of coronary artery disease in young adults undergoing clinically indicated coronary CT angiography(yeni sekmede açılır)

OGorman, K. J., Metser, G., Mullen, S., Ng, N., Leb, J., Zhang, Y., Shimbo, D., Rogers, C., Navas-Acien, A., Leipsic, J., Einstein, A. J.

Background The reported prevalence and burden of coronary artery disease in young adults varies markedly in published studies from the 1950s through 2000s but has not been evaluated in a large contemporary multicentre cohort of young adults referred for clinically indicated coronary CT angiography (CCTA). Methods…

Coronary angiography findings in emergency department chest pain patients undergoing angiography despite hs-cTnT-based early rule-out angiography after hs-cTnT rule-out in ED chest pain(yeni sekmede açılır)

Avlac, A., Altınbilek, E., Sönmez, B. M., Öztürk, D., Civelek, I., Celik, S.

Background High-sensitivity cardiac troponin (hs-cTn) algorithms are established for early rule-out of acute myocardial infarction, but coronary angiographic (CAG) findings in emergency department (ED) patients undergoing invasive evaluation despite fulfilling rule-out criteria remain insufficiently described.…

Patient radiation exposure during invasive graft surveillance after heart transplantation(yeni sekmede açılır)

Sazgary, L., Samara, E. T., Mikulicic, F., Frank, M., Parianos, D., Nägele, M. P., Ruschitzka, F., Flammer, A. J., Saguner, A. M.

Background Invasive procedures, including endomyocardial biopsy (EMB), right heart catheterisation (RHC) and coronary angiography (CA), are essential components of graft surveillance after heart transplantation (HTx). Fluoroscopy remains the primary imaging modality. Data on patient radiation exposure in HTx…

Successful off-label use of vascular closure devices in fully percutaneous transaxillary aortic valve implantation(yeni sekmede açılır)

Lauten, P., Bleiziffer, S., Costello-Boerrigter, L. C., Göbel, B., Albert, C., Al Jassem, M., Gonzalez-Lopez, D., Schieffer, B., Lapp, H.

Background The axillary artery is an alternative access- site for transcatheter aortic valve implantation (TAVI) when femoral arteries are unfavourable. Simplified transaxillary-TAVI (TAx-TAVI) is performed completely percutaneously, using vascular closure device (VCD) techniques for arteriotomy closure. Concerns…

C-reactive protein and 90-day adverse clinical outcomes in acute myocarditis: a retrospective database analysis of patients requiring hospitalisation(yeni sekmede açılır)

Marchetta, M., Filomia, S., Golino, M., Morini, S., Sicignano, L. L., Narducci, M. L., Sanna, T., Abbate, A., Del Buono, M. G.

Background C-reactive protein (CRP) is commonly used to assess systemic inflammation, yet its prognostic value in acute myocarditis remains uncertain. Evidence is limited by heterogeneous populations, variable CRP thresholds and differing outcome definitions. We therefore aimed to evaluate whether CRP levels measured…

Integrating RV-PA coupling and geometry-based indices into the TRI-SCORE improves prognostic assessment in tricuspid regurgitation(yeni sekmede açılır)

Mistrulli, R., Beles, M., De Oliveira, E. K., Vrenozaj, R., Gharehdaghi, S., Barbato, E., Paolisso, P., Spapen, J., Penicka, M., Vanderheyden, M., Rosseel, L., Praet, F. V., Hermans, H., Van Camp, G.

Background Tricuspid regurgitation (TR) is a progressive and underdiagnosed condition associated with poor prognosis. Although the TRI-SCORE is a validated risk model for patients undergoing tricuspid valve surgery, it does not incorporate echocardiographic measures of right ventricular (RV) function or…

Effects of early continuous renal replacement therapy in critically ill patients requiring ECMO treatment: results of a randomised controlled trial(yeni sekmede açılır)

Wang, X., Liu, Y., Wang, Z., Wang, H., Li, C., Tian, J., Wang, C., Liu, X., Li, J., Yin, Y., Lv, L., Wu, Y., Li, B., Wang, Y., Zhang, S., Li, X., Anderson, C. S., Du, X., Dong, J., Hou, X.

Background Extracorporeal membrane oxygenation (ECMO) is increasingly used to treat patients with severe cardiac and pulmonary failure but the complications of acute kidney injury and fluid overload are common. We aimed to determine whether the early initiation of continuous renal replacement therapy (CRRT) can reduce…